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To replicate specific mitochondrial GSH mechanisms and data from in vivo mice models, a mitochondrial compartment needs to be added

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Our model is in agreement with the local S-palmitoylation described for substrates such as PSD-95 at dendritic spines 37 and calnexin at the ER 47 , but adds the Golgi as a compartment in which PMPs can be locally modified and retained